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In certain embodiments, allopurinol cost cvs either one or both of the gene encoding the revTetR repressor and the gene encoding the tetracycline-regulated indicator gene are integrated, for example, into the att site in Bacillus subtilis using bacteriophage Φ11 or, alternatively, integrated into the chromosome via homologous recombination into a specified gene (e.g., amiA gene; see Brucker 1997 FEMS Microbiol.